CAY10795
Catalogue number:
CAY37981-10 mg
Supplier:
Size:
10 mg
Product is available in:
£733.00
Estimated delivery Fri 9 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2241676-74-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
398.5
Alternative Names:
2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]-1(2h)-isoquinolinone, 15-hydroxy prostaglandin dehydrogenase inhibitor, 15-pgdh inhibitor
- Data sheet: View or download
- MSDS: View or download
Product Description:
A 15-PGDH inhibitor (IC50 = 3 nM); increases PGE2 levels >3-fold in IL-1β-stimulated A549 cells at 500 nM; reduces 15-PGDH activity in the colon of mice at 20 mg/kg and limits decreases in body weight and colon length and reduces colon ulceration in a mouse model of DSS-induced ulcerative colitis at 40 mg/kg; accelerates recovery of circulating neutrophils following whole-body radiation and bone marrow transplant in mice at 10 mg/kg twice per day
Storage Temperature:
-20°C