SKA-121
Catalogue number:
CAY9003088-25 mg
Supplier:
Size:
25 mg
Product is available in:
£733.00
Estimated delivery Fri 9 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1820708-73-3
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
198.2
Alternative Names:
5-methyl-naphth[2,1-d]oxazol-2-amine
- Data sheet: View or download
- MSDS: View or download
Product Description:
A positive-gating modulator of IKCa1/KCa3.1 channels (EC50 = 109 nM); selective for KCa3.1 over KCa2.1, KCa2.2 and KCa2.3 (EC50s = 8,700, 6,800, and 4,400 nM, respectively), KCa1.1 as well as voltage-gated potassium and sodium channels; potentiates calcium-evoked KCa currents by approximately 7-fold (1 µM) as well as calcium-evoked and basal KCa currents; potentiates bradykinin-induced endothelium-dependent relaxation (EC50 = 7.9 nM) in large porcine coronary arteries ex vivo; lowers MAP ) by approximately 20 and 25 mm Hg in normo- and hypertensive mice (100 mg/kg)
Storage Temperature:
-20°C