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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
574759-62-9
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
349.7
Alternative Names:
4-(3-chlorophenyl)-n-[4-(trifluoromethyl)phenyl]-2-pyrimidinamine
- Data sheet: View or download
- MSDS: View or download
Product Description:
An AhR agonist; binds to AhR in a radioligand binding assay using guinea pig hepatic cytosol and induces mRNA expression of CYP1A1 in isolated human PBMCs at 50 nM; inhibits 1,25-dihydroxy vitamin D3-induced differentiation and promotes all-trans retinoic acid-induced differentiation of HL-60 cells at 20 µM; decreases serum IgE levels and lung and BALF eosinophil infiltration in an ovalbumin-induced mouse model of allergic inflammation at 30 mg/kg; prevents retinal capillary degeneration in a mouse model of STZ-induced diabetic retinopathy at 30 mg/kg
Storage Temperature:
-20°C