MKC8866
Catalogue number:
CAY37332-5 mg
Supplier:
Size:
5 mg
Product is available in:
£144.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1338934-59-0
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
361.4
Alternative Names:
7-hydroxy-6-methoxy-4-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-2-oxo-2h-1-benzopyran-8-carboxaldehyde, inositol-requiring enzyme 1α inhibitor 8866, ire1-in-8866
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of IRE1α RNase activity (IC50 = 0.29 µM); inhibits DTT-induced production of XBP1 in MM.1S multiple myeloma cells (EC50 = 0.52 µM) and thapsigargin-induced XBP1 production in LNCaP cells (IC50 = 0.38 µM); decreases expression of the XBP1 target genes SREBF1, DGAT2, and LIPE and increases triglyceride levels in MDA-MB-231 cells; reduces tumor volume in LNCaP, VCaP, 22Rv1, and C4-2B prostate cancer mouse xenograft models at 300 mg/kg
Storage Temperature:
-20°C