ETP-46321
Catalogue number:
CAY37330-1 mg
Supplier:
Size:
1 mg
Product is available in:
£65.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1252594-99-2
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
473.6
Alternative Names:
5-[2-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-8-(4-morpholinyl)imidazo[1,2-a]pyrazin-6-yl]-2-pyrimidinamine
- Data sheet: View or download
- MSDS: View or download
Product Description:
A PI3K p110α and p110δ inhibitor (apparent Kis = 2.3 and 14.2 nM, respectively); selective for PI3K p110α and p110δ over p110β and p110γ (apparent Kis = 170 and 179 nM, respectively), as well as a panel of 288 kinases at 1 µM; inhibits Akt phosphorylation in U2OS cells (IC50 = 8.3 nM); reduces tumor volume in a K-RasG12V-driven murine lung tumor model at 50 mg/kg; reduces anti-collagen IgG1 and IgG2a production, swelling, and joint rigidity in a mouse model of collagen-induced arthritis
Storage Temperature:
-20°C