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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1247018-19-4
Purity:
≥95%
Formulation:
A solid
Molecular Weight:
510.6
Alternative Names:
n-[2-[(4-cyano-2-fluorophenyl)[(1-methyl-1h-imidazol-5-yl)methyl]amino]ethyl]-n-(cyclohexylmethyl)-2-pyridinesulfonamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
A dual inhibitor of FTase and GGTase I (IC50s = 250 and 520 nM, respectively); inhibits prenylation of H-Ras and Rap1A (IC50s = 88.7 and 2,700 nM, respectively) in oncogenic H-Ras-transformed NIH3T3 cells; inhibits membrane localization of K-Ras in MIA PaCa-2 and H460 cancer cells at 10 and 30 µM; reduces tumor growth, increases intratumoral expression of p53, induces intratumoral apoptosis, and decreases intratumoral HDJ2 farnesylation and Rap1A geranylgeranylation in PDX mouse models of mutant KRAS-expressing pancreatic cancer at 50 and 100 mg/kg per day
Storage Temperature:
-20°C