£265.00
Estimated delivery Tue 16 Jul
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1247018-19-4
Purity:
≥95%
Formulation:
A solid
Molecular Weight:
510.6
Alternative Names:
n-[2-[(4-cyano-2-fluorophenyl)[(1-methyl-1h-imidazol-5-yl)methyl]amino]ethyl]-n-(cyclohexylmethyl)-2-pyridinesulfonamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
A dual inhibitor of FTase and GGTase I (IC50s = 250 and 520 nM, respectively); inhibits prenylation of H-Ras and Rap1A (IC50s = 88.7 and 2,700 nM, respectively) in oncogenic H-Ras-transformed NIH3T3 cells; inhibits membrane localization of K-Ras in MIA PaCa-2 and H460 cancer cells at 10 and 30 µM; reduces tumor growth, increases intratumoral expression of p53, induces intratumoral apoptosis, and decreases intratumoral HDJ2 farnesylation and Rap1A geranylgeranylation in PDX mouse models of mutant KRAS-expressing pancreatic cancer at 50 and 100 mg/kg per day
Storage Temperature:
-20°C