Semagacestat
Catalogue number:
CAY16713-5 mg
Supplier:
Size:
5 mg
Product is available in:
£117.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
425386-60-3
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Weight:
361.4
Alternative Names:
(2s)-2-hydroxy-3-methyl-n-[(1s)-1-methyl-2-oxo-2-[[(1s)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1h-3-benzazepin-1-yl]amino]ethyl]-butanamide, ly450139
- Data sheet: View or download
- MSDS: View or download
Product Description:
A potent inhibitor of γ-secretase that blocks the production of Aβ38, Aβ40, and Aβ42 with IC50 values of 12.0, 12.1, and 10.9 nM, respectively; also blocks Notch signaling (IC50 = 14.1 nM); modulates γ-secretase activity in vivo, altering Aβ levels in brain, cerebrospinal fluids, and plasma in a dose-dependent fashion
Storage Temperature:
-20°C
