Sauchinone
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177931-17-8
≥98%
A crystalline solid
356.4
(5ar,7r,8s,8ar,14as,14br)-5a,6,7,8,8a,14b-hexahydro-7,8-dimethyl-5h-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one
- Data sheet: View or download
- MSDS: View or download
A lignan with diverse biological activities; inhibits LPS-induced expression of the genes encoding iNOS, TNF-α, and COX-2 (IC50s = ≤10 µM for all), as well as LPS-induced activation of NF-κB and nuclear translocation of NF-κB p65 in RAW 264.7 cells; reduces hydrogen peroxide-induced increases in Hsp70 levels and cell death in C2C12 mouse skeletal muscle myoblasts; reduces hepatic formation of TBARS, plasma levels of ALT, and hepatocyte cell death in a mouse model of iron overload-induced liver injury at 10 and 30 mg/kg; reduces infarct size and heart levels of phosphorylated p38 MAPK and JNK in a rat model of myocardial ischemia-reperfusion injury
-20°C
