Riociguat
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625115-55-1
≥98%
A crystalline solid
422.4
n-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1h-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-n-methyl-carbamic acid, methyl ester, bay 63-2521
- Data sheet: View or download
- MSDS: View or download
A stimulator of sGC; stimulates recombinant sGC in a concentration-dependent manner in vitro by up to 73-fold at 100 µM or by up to 112-fold when used in combination with DEA NONOate; has no effect on phosphodiesterases PDE1-9 and PDE11 at ≤3 µM; reduces pulmonary and systemic arterial pressure at 1 and 10 mg/kg in a rabbit model of acute PAH induced by U-46619; inhibits increases in right ventricular systolic pressure, right heart hypertrophy, and pulmonary artery muscularization in hypoxia-induced mouse and monocrotaline-injected rat models of chronic PAH at 10 mg/kg
-20°C
