N-(n-Butyl)deoxygalactonojirimycin
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141206-42-0
≥95%
A crystalline solid
219.3
1-butyl-2r-(hydroxymethyl)-3s,4r,5s-piperidinetriol, lucerastat, nbdgj
- Data sheet: View or download
- MSDS: View or download
An inhibitor of glucosylceramide synthase, GBA, GBA2, acid α-glucosidase, sucrase, maltase, and lactase; reduces glycolipid levels in HL-60 and WEHI-3B cells from 0.5-500 µM; decreases brain ganglioside levels in a Glb1-/-neonatal mouse model of GM1 gangliosidosis at 600 and 1,200 mg/kg four times per day for three days; increases testicular glucosylceramide levels in mice from 1-1,200 mg/kg per day for 35 days; induces abnormal spermatid and acrosome formation, as well as reduces motility, in isolated mouse epididymal sperm at 15, 25, and 50 mg/kg per day; induces infertility, an effect that is reversed by withdrawal, in the same model
-20°C
