Entrectinib
Catalogue number:
CAY19476-1 mg
Supplier:
Size:
1 mg
Product is available in:
£47.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1108743-60-7
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
560.6
Alternative Names:
n-[5-[(3,5-difluorophenyl)methyl]-1h-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2h-pyran-4-yl)amino]-benzamide, nms-e628, rxdx-101
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of TrkA (IC50 = 1.7 nM), TrkB (IC50 = 0.1 nM), and TrkC (IC50 = 0.1 nM), as well as ROS1 (IC50 = 0.2 nM) and ALK (IC50 = 1.6 nM); blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance mutations; induces tumor regression in mice bearing various Trk, ROS1, or ALK-driven xenografts
Storage Temperature:
-20°C
