Alaproclate (hydrochloride)
Catalogue number:
CAY27770-5 mg
Supplier:
Size:
5 mg
Product is available in:
£64.00
Estimated delivery Fri 9 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
60719-83-7
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Weight:
292.2
Alternative Names:
alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester, monohydrochloride, a03, gea 654
- Data sheet: View or download
- MSDS: View or download
Product Description:
An SSRI; inhibits depletion of 5-HT induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively); inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 µM, respectively); increases SIRT1 levels in N2a murine neuroblastoma cells expressing ApoE4 (IC50 = 2.3 µM) and in the hippocampus in the FXFAD-ApoE4 transgenic mouse model of Alzheimer’s disease at 20 mg/kg twice daily; decreases immobility time in the forced swim test in rats at 40 mg/kg
Storage Temperature:
-20°C
