Lacidipine
Shipping is calculated in checkout
103890-78-4
≥98%
A solid
455.5
4-[2-[(1e)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester, gr 43659x, gx 1048
- Data sheet: View or download
- MSDS: View or download
An L-type calcium channel blocker; inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4); induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7, 6, and 7.8 nM, respectively); induces negative inotropy in isolated guinea pig ventricular strips (IC50 = 110 nM); reduces mean blood pressure in spontaneously hypertensive rats (ED25 = 0.35 mg/kg) and in renal hypertensive dogs (ED25 = 0.22 mg/kg); inhibits copper-induced oxidation of isolated human LDL at 1 and 5 µM; reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/- mice in a model of Western diet-induced atherosclerosis
-20°C
