£553.00
Estimated delivery Fri 2 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1258392-53-8
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
1015.3
Alternative Names:
3,3′-[2,4-hexadiyne-1,6-diylbis[oxy[(1s,2r)-2,3-dihydro-1h-indene-2,1-diyl]]]bis[n-methyl-l-alanyl-(2s)-2-cyclohexylglycyl-l-prolinamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
A Smac mimetic and IAP inhibitor; binds to the BIR3 domains of IAP1, IAP2, and XIAP (IC50s = 15, 21, and 15 nM, respectively); disrupts the protein-protein interaction between IAP1 and caspase-9 in vitro; induces degradation of IAP1 in (EC50 = 0.1 nM) and reduces the growth of MDA-MB-231 breast cancer cells (GI50 = + T cell, spleen, thymus, bone marrow, liver, lung, and lymph node levels of HIV RNA in a humanized mouse model of antiretroviral therapy-suppressed HIV infection at 3 mg/kg
Storage Temperature:
-20°C