£624.00
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2229039-45-4
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
296.3
Alternative Names:
6-[2-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-2(1h)-quinolinone
- Data sheet: View or download
- MSDS: View or download
Product Description:
A BRD4 inhibitor; inhibits BD1 and BD2 in BRD4 (IC50s = 27 and 32 nM, respectively); selective for BD1 and BD2 in BRD4 over BD1 in BRD2, BRD3, and BRDT (IC50s = 803, 2,275, and 3,183 nM, respectively) and BD2 (IC50s = 1,736, 2,193, and 2,781 nM, respectively), as well as the bromodomain in CBP (IC50 = >10,000 nM); inhibits neutrophil infiltration around small- and medium-sized airways and reduces cytokine expression in lung tissue in a poly(I:C)-induced mouse model of acute airway inflammation at 10 mg/kg
Storage Temperature:
-20°C