SGC-iMLLT
Catalogue number:
CAY28113-10 mg
Supplier:
Size:
10 mg
Product is available in:
£212.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2255338-25-9
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
388.5
Alternative Names:
1-methyl-n-[2-[[(2s)-2-methyl-1-pyrrolidinyl]methyl]-1h-benzimidazol-6-yl]-1h-indazole-5-carboxamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of the YEATS domain-containing proteins MLLT1 and MLLT3; binds to the MLLT1 YEATS1 and MLLT3 YEATS3 domains (Kds = 129 and 77 nM, respectively); selective for YEATS1 and -3 over YEATS2 and -4 (IC50s = >10 µM), as well as a panel of 48 bromodomains at 50 µM; inhibits histone H3.3 interactions with MLLT3 (IC50 = 400 nM in a reporter assay); decreases expression of MYC and DDN in MV-4-11 leukemia cells at 1 µM
Storage Temperature:
-20°C