ON-123300
Catalogue number:
CAY19902-1 mg
Supplier:
Size:
1 mg
Product is available in:
£48.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1357470-29-1
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
429.5
Alternative Names:
8-cyclopentyl-7,8-dihydro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-oxo-pyrido[2,3-d]pyrimidine-6-carbonitrile
- Data sheet: View or download
- MSDS: View or download
Product Description:
A multi-kinase inhibitor; inhibits ARK5, Cdk4, and Cdk6 (IC50s = 3.87, 9.82, and 4.95 nM, respectively); inhibits FYN, PDGFRβ, Abl, and PI3Kδ (IC50s = 11.09, 26, 53.32, and 144 nM, respectively) among others; inhibits proliferation in a panel of 38 cancer cell lines (GI50s = 0.05-5 µM); also inhibits proliferation of U87 glioma cells (IC50 = 3.4 µM); reduces tumor growth in an MDA-MB-231 mouse xenograft model at 50 mg/kg every other day
Storage Temperature:
-20°C
